Drug mixtures present on the drugs market may cause additional harms alongside those traditionally observed, due to issues such as user-unknown content, varying contents, the presence of harmful ingredients, or possible drug interactions, to name a few.

• New drug mixtures such as "tuci" pink cocaine, kush "happy water" are emerging on the market, but evidence their chemical composition and health impact remains limited.
• In addition to pre-prepared mixtures, people who use drugs sometimes prepare their own drug mixtures, such as "nyaope" or "whoonga" in South Africa whose analysed samples contained cannabis, caffeine, heroin, codeine, morphine, methyl-dioxy amphetamine (MDA) arbiturates, benzodiazepines, antiretroviral drugs and other pharmaceuticals. Many sources even name rat poison or domestic cleaning chemicals as ingredients.
• Several mostly user-prepared mixtures were also described in Nigeria, for example "zobo" (a drink containing cannabis, "crack" cocaine and alcohol among other substances), utterater (a cocktail of tramadol, cannabis, codeine,rohypnol and alcohol) or onkeyail (a cocktail of homemade gin, cannabis seeds, leaves, stems, and roots).
• Information on use and trafficking of new mixtures is scarce due to the additional complexities of self-reporting use of partially unknown mixtures and the lack of laboratory analysis of certain blends.