Drug use & health consequences>>Drug-Related Harm

Direct drug-related deaths

More countries perceive an increase in drug-related deaths in 2024 than decrease.

  • Toxicological findings reported by 66 countries suggest that opioids are found in direct drug-related deaths far more than other drug types, but cocaine has overtaken (albeint by a small margin) pharmaceutical sedatives and tranquilizers used non-medically, as the second most common drug.
  • The limited number of countries that reported sex-disaggregated data of direct-drug related deaths suggest that females are more likely to die in relation to sedatives and tranquilizers (33 percent, average of 35 countries) than in relation to other drugs.
  • In the United States, the country with the highest number of drug-related deaths globally, the largest category causing deaths remained opioids in 2023. Females constitute about thirty per cent of all drug overdoses with their highest share (55%) among the relatively small number of deaths associated with antidepressants.
  • Global estimates by IHME confirm the dominance of opioids as the most common cause of direct drug-related deaths, with a considerable increase over the past three decades, but especially over the last decade, with this trend possibly slowing down.