Cannabis remains the most widely used drug globally, with large differences across substances and regions.

• With an estimated 256 million users in 2024, cannabis remains by far the most used drug worldwide, followed by the non-medical use of opioids at 63 million.
• Men have a higher prevalence of drug use than women across all drugs, although the sex differences vary by drug.
• The prevalence of use of all drugs among people aged 15-16 is similar to or higher than among the general population aged 15-64.
• The prevalence of use of different drugs and the number of people using them varies by region and subregion.