Synthetic drug markets vary widely, with different substances dominating across countries and regions

• The most commonly used synthetic drugs differ by region: non-medical use of tramadol dominates West and Central Africa and methamphetamine is most prevalent in East and South-East Asia.
• New psychoactive substances, mainly synthetic cathinones, play a major role in Eastern Europe and Central Asia, whereas amphetamine (including "captagon") is most commonly used in the Near and Middle East.