Availability of internationally controlled pharmaceutical opioids for medical use has stabilized in recent years.Availability of pharmaceutical opioids for medical use more than doubled between 1998 and 2024 – driven by a strong increase until 2013, followed by a decline and partial recovery in…
There remains a large discrepancy between the Global North and the Global South in the availability of internationally controlled pharmaceutical opioids for medical use - even though the gap is declining.Between 2015 and 2024, the per capita availability of pharmaceutical opioids for medical use in…
Heroin and morphine seizures remain concentrated in Asia.In line with the concentration of opium production in Asia, almost two thirds (64 per cent) of global heroin and morphine seizures occurred in Asia in 2024, notably in South-Western Asia and, to a lesser extent, in East and South-East Asia.In…
Seizures of key pharmaceutical opioids show distinct regional patterns by substance.While fentanyl seizures remain overwhelmingly concentrated in North America (> 99 per cent), other pharmaceutical opioids dominate seizures in different regions: codeine in West and Central Africa and South Asia…
Global illicit opium production remained more than 70 per cent below 2022 levels in 2025Global illicit opium production remained at lower levels in 2025 at 2,100 tons, more than 70 per cent below 2022 (mainly due to Afghanistan’s opium ban) and almost 80 per cent below its 2017 peak.A doubling of…
The global NPS market continues to evolve rapidly, with new substances entering the market and shifting preferences.By 2025, the total number of NPS identified by Member States since 2005 grew close to 1,500 which – despite the scheduling of new substances in 2025 – is more than four times the…
The illicit ketamine market has expanded beyond Asia, with rising use and emerging harms in new regions.Once concentrated in East and South-East Asia, several countries with time-series data (for example, the United Kingdom, Australia or the United States) have recorded an increase in the use of…
Seven substances dominate the global availability of opioids under international control for medical consumption.Expressed in S-DDDs (defined daily doses for statistical purposes), methadone, followed by hydrocodone, fentanyl, buprenorphine, oxycodone, codeine (including preparations) and morphine…
The type of opioid that is most used non-medically varies across regions and countries.With the highest population globally, Asia is also the region with the highest number of people who use opioids.The type of opioid used differs across regions, with opiates such as heroin dominating in Asia and…
Similarly to most internationally controlled drugs, the use of NPS among adolescents is higher than among the general population, but the difference between adolescent boys and girlsis lower for NPS than for controlled drugs.Limited data suggest that NPS use is generally higher among school…
The use of buprenorphine and methadone for medical purposes continues to expandMethadone and buprenorphine are the main substances used in substitution treatment for opioid dependent persons worldwide. Availability of both substances for medical use rose 10-fold over the last two decades and…
Opium production and opiate seizures are closely linked, but stockpiling has partly mitigated recent supply shocks.Opiate seizures have generally moved in parallel with opium production over time, but production has been far more volatile. Following the transfer of power in Afghanistan in 2021 and…
