The type of opioid that is most used non-medically varies across regions and countries.With the highest population globally, Asia is also the region with the highest number of people who use opioids.The type of opioid used differs across regions, with opiates such as heroin dominating in Asia and…
The non-medical use and trafficking of tramadol remain most concentrated in North Africa, West and Central Africa, and the Near and Middle East and South-West Asia, though there remains significant localized non-medical use in other regions.There remains a significant data gap on tramadol use and…
Similarly to most internationally controlled drugs, the use of NPS among adolescents is higher than among the general population, but the difference between adolescent boys and girlsis lower for NPS than for controlled drugs.Limited data suggest that NPS use is generally higher among school…
The health harms posed by the non-medical use of opioids remains high in North America, but have started to decline in late 2023 and in 2024.Opioid overdose deaths reached historical highs in the United States of America and Canada between 2021 and 2023 but have since started to decline, returning…
In East and South-East Asia, limited regular data collection makes it difficult to assess long-term trends in opioid use. However, data on people registered for drug use and people in drug treatment indicate a decline in opioid (mainly heroin) use over the past 10 to 15 years.In most of East and…
Opioid-related harms, measured as new people entering treatment, have declined in Europe.Although the share of people in treatment for opioid use disorders remains substantial in Europe, the number of people entering treatment for the first time has decreased.In Eastern Europe and South-Eastern…
The use of buprenorphine and methadone for medical purposes continues to expandMethadone and buprenorphine are the main substances used in substitution treatment for opioid dependent persons worldwide. Availability of both substances for medical use rose 10-fold over the last two decades and…
Opium production and opiate seizures are closely linked, but stockpiling has partly mitigated recent supply shocks.Opiate seizures have generally moved in parallel with opium production over time, but production has been far more volatile. Following the transfer of power in Afghanistan in 2021 and…
Opium prices show diverging trends, reflecting shifting supply dynamics across producing countries.Opium poppy cultivation in Myanmar, increased by 17 per cent in 2025 and more than doubled since 2020, with increases reported across all poppy producing states; this was mirrored by a similar…
The number of NPS on the global market increased strongly in 2024 following a short period of decline between 2021 and 2023.The number of NPS on the global market rose by 30 per cent in 2024 compared to 2023 and reached a new record high of 755 substances – the number rose almost five-fold compared…
Trend data on seizures suggest that the trafficking in (and misuse of) pharmaceutical opioids increased strongly over the last decade, reaching record levels in 2024.The largest volumes of pharmaceutical opioids were seized in Africa (60 per cent – mostly in West and Central Africa) and Asia (33…
While remaining at low levels in recent years, seizures of plant-based NPS are increasingly dominated by kratom, followed by khat.In contrast to the upward trend in seizures of synthetic NPS, seizures of plants-based drugs fluctuated while remaining at low levels over the 2021-2024 period. Overall…
